東京慈恵会医科大学 薬理学講座

論文

青木友浩
C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms. Akihiro Okada, Kampei Shimizu, Akitsugu Kawashima, Tomomichi Kayahara, Masahiko Itani, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki. Scientific reports 14(1) 3105-3105 2024年2月7日

Time-of-flight and black-blood MRI to study intracranial arteries in rats. Anne F. Cayron, Olivia Bejuy, Maria Isabel Vargas, Didier Colin, Tomohiro Aoki, Karl-Olaf Lövblad, Philippe Bijlenga9, Brenda R. Kwak, Eric Allémann, Sandrine Morel. European Radiology Experimental 8: 3 2024

中村行宏
GABA B receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles. Peter Koppensteiner, Pradeep Bhandari, Cihan Önal, Carolina Borges-Merjane, Elodie Le Monnier, Utsa Roy, Yukihiro Nakamura, Tetsushi Sadakata, Makoto Sanbo, Masumi Hirabayashi, JeongSeop Rhee, Nils Brose, Peter Jonas, Ryuichi Shigemoto. Proceedings of the National Academy of Sciences 2024年2月20日

鈴木江津子
Enhancement of haloperidol-induced catalepsy by GPR143, an L-DOPA receptor, in striatal cholinergic interneurons. Masami Arai, Etsuko Suzuki, Satoshi Kitamura, Momoyo Otaki, Kaori Kanai, Miwako Yamasaki, Masahiko Watanabe, Yuki Kambe, Koshi Murata, Yuuki Takada, Tetsu Arisawa, Kenta Kobayashi, Rei Tajika, Tomoyuki Miyazaki, Masahiro Yamaguchi, Michael Lazarus, Yu Hayashi, Shigeyoshi Itohara, Alban de Kerchove d'Exaerde, Hiroyuki Nawa, Ryang Kim, Haruhiko Bito, Toshihiko Momiyama, Daiki Masukawa, Yoshio Goshima. The Journal of Neuroscience 2024年1月29日

書籍

石川太郎
生理学用語ハンドブック（分担執筆）. 丸善出版 2024年
志牟田美佐
ジェンダー事典（分担執筆 第13章 学術と科学）. 丸善出版 2024年

論文

青木友浩
Hypoxic microenvironment as a crucial factor triggering events leading to rupture of intracranial aneurysm. Isao Ono, Tomomichi Kayahara, Akitsugu Kawashima, Akihiro Okada, Susumu Miyamoto, Hiroharu Kataoka, Hiroki Kurita, Akira Ishii, Tomohiro Aoki. Scientific reports 13(1) 5545-5545 2023年4月

脳動脈瘤を例に炎症を考える. 栢原智道、井谷理彦、青木友浩. 脳神経外科 51( 5); 931-940 2023

西晴久
Degranulation of human mast cells: modulation by P2 receptors’ agonists. Edward S. Schulman, Haruhisa Nishi, Amir Pelleg. Frontiers in Immunology 14 2023年10月5日

書籍

青木友浩
脳動脈瘤の基礎実験；発生・増大・破裂メカニズム. 青木友浩. エビデンスとガイドラインに基づく脳動脈瘤とくも膜下出血2-15. 医学書院 2023

鈴木江津子
第６章 動物の学習から探る──どのように学び，忘れるのか？ 6-1. 鈴木江津子. 動物心理学入門 : 動物行動研究から探るヒトのこころの世界. 有斐閣 2023年

論文

青木友浩
Endothelial cell malfunction in unruptured intracranial aneurysm lesions revealed using a 3D-casted mold. Isao Ono, Yu Abekura, Akitsugu Kawashima, Mieko Oka, Akihiro Okada, Shintaro Hara, Susumu Miyamoto, Hiroharu Kataoka, Akira Ishii, Kimiko Yamamoto, Tomohiro Aoki. Journal of neuropathology and experimental neurology 82(1) 49-56 2022年12月

Identification of The Unique Subtype of Macrophages in Aneurysm Lesions at the Growth Phase. Akihiro Okada, Hirokazu Koseki, Isao Ono, Tomomichi Kayahara, Hiroki Kurita, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 31(12) 106848-106848 2022年12月

Associations Between Drug Treatments and the Risk of Aneurysmal Subarachnoid Hemorrhage: a Systematic Review and Meta-analysis. Kampei Shimizu, Tomohiro Aoki, Nima Etminan, Katharina A M Hackenberg, Shoichi Tani, Hirotoshi Imamura, Hiroharu Kataoka, Nobuyuki Sakai. Translational stroke research 2022年10月

The bifurcation angle is associated with the progression of saccular aneurysms. Kampei Shimizu, Hiroharu Kataoka, Hirohiko Imai, Takeshi Miyata, Akihiro Okada, Nobuyuki Sakai, Masaki Chin, Koichi Iwasaki, Taketo Hatano, Hirotoshi Imamura, Ryota Ishibashi, Masanori Goto, Masaomi Koyanagi, Tomohiro Aoki, Susumu Miyamoto. Scientific reports 12(1) 7409-7409 2022年5月

The cerebral artery in cynomolgus monkeys (Macaca fascicularis). Keiichi Tsuji, Shinichiro Nakamura, Tomohiro Aoki, Kazuhiko Nozaki. Experimental animals 2022年4月

[Current Knowledge on the Genetic Analysis and Development of Medical Therapy for Intracranial Aneurysms]. Tomohiro Aoki, Tomomichi Kayahara, Isao Ono, Akihiro Okada. No shinkei geka. Neurological surgery 50(1) 179-195 2022年1月

石川太郎
SCA42モデルマウスに対するエトサクシミドの治療効果. 大久保 正紀, 土井 宏, 橋口 俊太, 高橋 慶太, 田中 健一, 竹内 英之, 石川 太郎, 田中 章景. 神経治療学 39(6) S234-S234 2022年10月

志牟田美佐
新型コロナウイルス感染拡大に伴う 第一回緊急事態宣言が研究者・技術者へ与えた影響 ─弱い立場の研究者・技術者がさらなる困難に直面した. 志牟田美佐, 浜田盛久, 三宅恵子, 野尻美保子, 小口千明, 大坪久子. 日本の科学者 57(3) 154-161 2022年3月

鈴木江津子
Serotonin 5‐HT 1A and 5‐HT 1B receptor‐mediated inhibition of glutamatergic transmission onto rat basal forebrain cholinergic neurons. Takuma Nishijo, Etsuko Suzuki, Toshihiko Momiyama. The Journal of Physiology 600(13) 3149-3167 2022年7月

書籍

青木友浩
くも膜下出血 病因と病態. 宮田悠, 青木友浩, 野崎和彦. 最新臨床脳卒中学第２版下. 株式会社 日本臨牀社 2022

脳動脈瘤発症増大の分子機序. 青木友浩, 岡田明大, 小野功朗, 栢原智道. 最新臨床脳卒中学第２版下. 株式会社 日本臨牀社 2022

脳動脈瘤病態の分子機序に基づく新規の診断治療の可能性. 青木友浩, 小野功朗, 栢原智道, 岡田明大. 最新臨床脳卒中学第２版上. 株式会社 日本臨牀社 2022

川村将仁
Ketogenic diet and adenosine in epilepsy - models and mechanisms. Kawamura M, Jr.. Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease (2nd ed.). Oxford University Press 2022

論文

青木友浩
Induction of CCN1 in Growing Saccular Aneurysms: A Potential Marker Predicting Unstable Lesions. Kampei Shimizu, Hirohiko Imai, Akitsugu Kawashima, Akihiro Okada, Isao Ono, Susumu Miyamoto, Hiroharu Kataoka, Tomohiro Aoki. Journal of neuropathology and experimental neurology 80(7) 695-704 2021年8月

Candidate drugs for preventive treatment of unruptured intracranial aneurysms: A cross-sectional study. Kampei Shimizu, Hirotoshi Imamura, Shoichi Tani, Hidemitsu Adachi, Chiaki Sakai, Akira Ishii, Hiroharu Kataoka, Susumu Miyamoto, Tomohiro Aoki, Nobuyuki Sakai. PloS one 16(2) e0246865 2021年

Hemodynamic Force as a Potential Regulator of Inflammation-Mediated Focal Growth of Saccular Aneurysms in a Rat Model. Kampei Shimizu, Hiroharu Kataoka, Hirohiko Imai, Yuto Yamamoto, Tomohiro Yamada, Haruka Miyata, Hirokazu Koseki, Yu Abekura, Mieko Oka, Mika Kushamae, Isao Ono, Susumu Miyamoto, Masanori Nakamura, Tomohiro Aoki. Journal of neuropathology and experimental neurology 80(1) 79-88 2021年1月

川村将仁
Leucine-Enriched Essential Amino Acids Enhance the Antiseizure Effects of the Ketogenic Diet in Rats. Fumika Takeuchi, Natsumi Nishikata, Mai Nishimura, Kenji Nagao, Masahito Kawamura. Frontiers in Neuroscience 15 2021年3月

西晴久
Enhancement of Mast Cell Degranulation Mediated by Purinergic Receptors' Activation and PI3K Type δ. Haruhisa Nishi, François Niyonsaba, Amir Pelleg, Edward S Schulman. Journal of immunology (Baltimore, Md. : 1950) 207 1-8 2021年7月

書籍

青木友浩
脳動脈瘤モデル（橋本モデル）. 青木友浩. 疾患モデルの作製と利用‐循環器疾患2021. エル・アイ・シー 2021

鈴木江津子
有斐閣現代心理学辞典（分担執筆：30項目担当）. 鈴木江津子. 有斐閣 2021年

論文

青木友浩
Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms in rats. Mika Kushamae, Haruka Miyata, Manabu Shirai, Kampei Shimizu, Mieko Oka, Hirokazu Koseki, Yu Abekura, Isao Ono, Kazuhiko Nozaki, Tohru Mizutani, Tomohiro Aoki. Scientific reports 10(1) 20004-20004 2020年11月

Hemodynamic and Histopathological Changes in the Early Phase of the Development of an Intracranial Aneurysm. Hiroharu Kataoka, Takanobu Yagi, Taichi Ikedo, Hirohiko Imai, Koichi Kawamura, Kazumichi Yoshida, Masanori Nakamura, Tomohiro Aoki, Susumu Miyamoto. Neurologia medico-chirurgica 60(7) 319-328 2020年7月

The Bilateral Ovariectomy in a Female Animal Exacerbates the Pathogenesis of an Intracranial Aneurysm. Mieko Oka, Isao Ono, Kampei Shimizu, Mika Kushamae, Haruka Miyata, Takakazu Kawamata, Tomohiro Aoki. Brain sciences 10(6) 2020年5月

Dedifferentiation of smooth muscle cells in intracranial aneurysms and its potential contribution to the pathogenesis. Mieko Oka, Satoshi Shimo, Nobuhiko Ohno, Hirohiko Imai, Yu Abekura, Hirokazu Koseki, Haruka Miyata, Kampei Shimizu, Mika Kushamae, Isao Ono, Kazuhiko Nozaki, Akitsugu Kawashima, Takakazu Kawamata, Tomohiro Aoki. Scientific reports 10(1) 8330-8330 2020年5月

Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats. Yu Abekura, Isao Ono, Akitsugu Kawashima, Katsumi Takizawa, Hirokazu Koseki, Haruka Miyata, Kampei Shimizu, Mieko Oka, Mika Kushamae, Susumu Miyamoto, Hiroharu Kataoka, Akira Ishii, Tomohiro Aoki. Journal of neuroinflammation 17(1) 129-129 2020年4月

Two Diverse Hemodynamic Forces, a Mechanical Stretch and a High Wall Shear Stress, Determine Intracranial Aneurysm Formation. Hirokazu Koseki, Haruka Miyata, Satoshi Shimo, Nobuhiko Ohno, Kazuma Mifune, Kenjiro Shimano, Kimiko Yamamoto, Kazuhiko Nozaki, Hidetoshi Kasuya, Shuh Narumiya, Tomohiro Aoki. TRANSLATIONAL STROKE RESEARCH 11(1) 80-92 2020年2月

Rat Model of Intracranial Aneurysm: Variations, Usefulness, and Limitations of the Hashimoto Model. Aoki T, Miyata H, Abekura Y, Koseki H, Shimizu K. Acta neurochirurgica. Supplement 127 35-41 2020年

石川太郎
De novo CACNA1G variants in developmental delay and early-onset epileptic encephalopathies. Misako Kunii, Hiroshi Doi, Shunta Hashiguchi, Toyojiro Matsuishi, Yasunari Sakai, Mizue Iai, Masaki Okubo, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Hideyuki Takeuchi, Taro Ishikawa, Noriko Miyake, Hirotomo Saitsu, Naomichi Matsumoto, Fumiaki Tanaka. Journal of the neurological sciences 416 117047-117047 2020年7月

川村将仁
Adenosine and Ketogenic Treatments. David N. Ruskin, Masahito Kawamura, Susan A. Masino. Journal of Caffeine and Adenosine Research 10(3) 104-109 2020年9月

Mild hypothermia protects synaptic transmission from experimental ischemia through reduction in the function of nucleoside transporters in the mouse hippocampus. Yu Oyama, Kouki Ono, Masahito Kawamura. Neuropharmacology 163 107853-107853 2020年2月

志牟田美佐、石川太郎
Multiple signals evoked by unisensory stimulation converge onto cerebellar granule and Purkinje cells in mice. Misa Shimuta, Izumi Sugihara, Taro Ishikawa. Communications biology 3(1) 381-381 2020年7月

鈴木江津子
M1 muscarinic acetylcholine receptor‐mediated inhibition of GABA release from striatal medium spiny neurons onto cholinergic interneurons. Etsuko Suzuki, Toshihiko Momiyama European Journal of Neuroscience 2020年12月

論文

青木友浩
Vasa Vasorum Formation is Associated with Rupture of Intracranial Aneurysms. Haruka Miyata, Hirokazu Koseki, Kampei Shimizu, Yu Abekura, Mieko Oka, Tomohiro Aoki, Kazuhiko Nozaki. NEUROSURGERY 66 150-150 2019年9月

High-Fat Diet Intake Promotes the Enlargement and Degenerative Changes in the Media of Intracranial Aneurysms in Rats. Kampei Shimizu, Haruka Miyata, Yu Abekura, Mieko Oka, Mika Kushamae, Takakazu Kawamata, Tohru Mizutani, Hiroharu Kataoka, Kazuhiko Nozaki, Susumu Miyamoto, Tomohiro Aoki. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 78(9) 798-807 2019年9月

Vasa vasorum formation is associated with rupture of intracranial aneurysms. Haruka Miyata, Hirohiko Imai, Hirokazu Koseki, Kampei Shimizu, Yu Abekura, Mieko Oka, Takakazu Kawamata, Tetsuya Matsuda, Kazuhiko Nozaki, Shuh Narumiya, Tomohiro Aoki. Journal of neurosurgery 1-11 2019年8月

RNA sequencing analysis revealed the induction of CCL3 expression in human intracranial aneurysms. Tomohiro Aoki, Hirokazu Koseki, Haruka Miyata, Masayoshi Itoh, Hideya Kawaji, Katsumi Takizawa, Akitsugu Kawashima, Hiroshi Ujiie, Takashi Higa, Kenzo Minamimura, Toshikazu Kimura, Hidetoshi Kasuya, Kazuhiko Nozaki, Akio Morita, Hirotoshi Sano, Shuh Narumiya. Scientific reports 9(1) 10387-10387 2019年7月

Macrophage Imaging of Intracranial Aneurysms. Kampei Shimizu, Mika Kushamae, Tomohiro Aoki. NEUROLOGIA MEDICO-CHIRURGICA 59(7) 257-263 2019年7月

Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms. Juhana Frosen, Juan Cebral, Anne M. Robertson, Tomohiro Aoki. NEUROSURGICAL FOCUS 47(1) E21 2019年7月

Intracranial Aneurysm as a Macrophage-mediated Inflammatory Disease. Kampei Shimizu, Mika Kushamae, Tohru Mizutani, Tomohiro Aoki. NEUROLOGIA MEDICO-CHIRURGICA 59(4) 126-132 2019年4月

KRAS G12D or G12V Mutation in Human Brain Arteriovenous Malformations. Oka M, Kushamae M, Aoki T, Yamaguchi T, Kitazato K, Abekura Y, Kawamata T, Mizutani T, Miyamoto S, Takagi Y. World neurosurgery 126 e1365-e1373 2019年3月

T cell-intrinsic prostaglandin E2-EP2/EP4 signaling is critical in pathogenic TH17 cell-driven inflammation. Jinju Lee, Tomohiro Aoki, Dean Thumkeo, Ratklao Siriwach, Chengcan Yao, Shuh Narumiya. The Journal of allergy and clinical immunology 143(2) 631-643 2019年2月

Molecular events regulating the pathogenesis of intracranial aneurysms ~special insight on hemodynamics and chronic inflammation. Tomohiro Aoki. Journal of Biorheology 33(2) 28-32 2019年

Real-time Imaging of an Experimental Intracranial Aneurysm in Rats. Haruka Miyata, Kampei Shimizu, Hirokazu Koseki, Yu Abekura, Hiroharu Kataoka, Susumu Miyamoto, Kazuhiko Nozaki, Shuh Narumiya, Tomohiro Aoki. NEUROLOGIA MEDICO-CHIRURGICA 59(1) 19-26 2019年1月

中村行宏、　石川太郎
研究者の最新動向 脊髄小脳失調症新規モデルマウスを用いた病態解析. 土井 宏, 橋口 俊太, 中村 行宏, 石川 太郎, 田中 章景. Precision Medicine 2(13) 1260-1266 2019年12月

川村将仁
Adenosine A1 receptor-mediated protection of mouse hippocampal synaptic transmission against oxygen and/or glucose deprivation: a comparative study. Kawamura M Jr, Ruskin DN, Masino SA. Journal of neurophysiology 122(2) 721-728 2019年8月

中村行宏
EGTA can inhibit vesicular release in the nanodomain of single Ca2+ channels. Nakamura Y. Frontiers in Synaptic Neuroscience 11(26) 2019年10月

Underpinning heterogeneity in synaptic transmission by presynaptic ensembles of distinct morphological modules. Fekete A, Nakamura Y, Yang YM, Herlitze S, Mark MD, DiGregorio DA, Wang LY. Nature communications 10(1) 826 2019年2月

中村行宏、志牟田美佐、鈴木江津子、石川太郎
Ataxic phenotype with altered CaV3.1 channel property in a mouse model for spinocerebellar ataxia 42. Shunta Hashiguchi, Hiroshi Doi, Misako Kunii, Yukihiro Nakamura, Misa Shimuta, Etsuko Suzuki, Shigeru Koyano, Masaki Okubo, Hitaru Kishida, Masaaki Shiina, Kazuhiro Ogata, Fumiko Hirashima, Yukichi Inoue, Shun Kubota, Noriko Hayashi, Haruko Nakamura, Keita Takahashi, Atsuko Katsumoto, Mikiko Tada, Kenichi Tanaka, Toshikuni Sasaoka, Satoko Miyatake, Noriko Miyake, Hirotomo Saitsu, Nozomu Sato, Kokoro Ozaki, Kiyobumi Ohta, Takanori Yokota, Hidehiro Mizusawa, Jun Mitsui, Hiroyuki Ishiura, Jun Yoshimura, Shinichi Morishita, Shoji Tsuji, Hideyuki Takeuchi, Kinya Ishikawa, Naomichi Matsumoto, Taro Ishikawa, Fumiaki Tanaka. Neurobiology of disease 130 104516-104516 2019年10月

書籍

青木友浩
脳血管疾患の遺伝子異常の検索の意義. 青木 友浩. 脳神経外科周術期管理のすべて（改訂第5版）. メジカルビュー社 2019

論文

青木友浩
[Intracranial Aneurysm as an Inflammation-related Disease]. Aoki T, Koseki H, Miyata H, Abekura Y, Shimizu K. No shinkei geka. Neurological surgery 46(4) 275-294 2018年4月

Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis. Calum T. Robb, Henry J. McSorley, Jinju Lee, Tomohiro Aoki, Cunjing Yu, Siobhan Crittenden, Anne Astier, Jennifer M. Felton, Nicholas Parkinson, Adane Ayele, Richard M. Breyer, Stephen M. Anderton, Shuh Narumiya, Adriano G. Rossi, Sarah E. Howie, Emma Guttman-Yassky, Richard B. Weller, Chengcan Yao. Journal of Allergy and Clinical Immunology 141(1) 152-162 2018年1月

中村行宏
Two-component latency distributions indicate two-step vesicular release at simple glutamatergic synapses. Miki T, Nakamura Y, Malagon G, Neher E, Marty A. Nature communications 9(1) 3943 2018年9月

Variations in Ca2+ influx can alter chelator-based estimates of Ca2+ channel-synaptic vesicle coupling distance. Nakamura Y, Reva M, DiGregorio DA. The Journal of Neuroscience 38(16) 3971-3987 2018年4月

書籍

青木友浩
脳動脈瘤新生モデル（京都モデル）. 小関宏和, 宮田悠, 青木友浩. 完全版 脳血管内治療学. メディカ出版 2018

論文

青木友浩
Macrophage Imaging of Cerebral Aneurysms with Ferumoxytol: an Exploratory Study in an Animal Model and in Patients. Tomohiro Aoki, Makoto Saito, Hirokazu Koseki, Keiichi Tsuji, Atsushi Tsuji, Kiyoshi Murata, Hidetoshi Kasuya, Akio Morita, Shuh Narumiya, Kazuhiko Nozaki. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 26(10) 2055-2064 2017年10月

A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration. Rie Yamamoto, Tomohiro Aoki, Hirokazu Koseki, Miyuki Fukuda, Jun Hirose, Keiichi Tsuji, Katsumi Takizawa, Shinichiro Nakamura, Haruka Miyata, Nozomu Hamakawa, Hidetoshi Kasuya, Kazuhiko Nozaki, Yoshitaka Hirayama, Ichiro Aramori, Shuh Narumiya. BRITISH JOURNAL OF PHARMACOLOGY 174(13) 2085-2101 2017年7月

Dipeptidyl Peptidase-4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation. Taichi Ikedo, Manabu Minami, Hiroharu Kataoka, Kosuke Hayashi, Manabu Nagata, Risako Fujikawa, Sei Higuchi, Mika Yasui, Tomohiro Aoki, Miyuki Fukuda, Masayuki Yokode, Susumu Miyamoto. JOURNAL OF THE AMERICAN HEART ASSOCIATION 6(6) e004777- 2017年6月

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE(2)-Mediated Suppression of Antitumor Immunity. Tze Mun Loo, Fumitaka Kamachi, Yoshihiro Watanabe, Shin Yoshimoto, Hiroaki Kanda, Yuriko Arai, Yaeko Nakajima-Takagi, Atsushi Iwama, Tomoaki Koga, Yukihiko Sugimoto, Takayuki Ozawa, Masaru Nakamura, Miho Kumagai, Koichi Watashi, Makoto M. Taketo, Tomohiro Aoki, Shuh Narumiya, Masanobu Oshima, Makoto Arita, Eiji Hara, Naoko Ohtani. CANCER DISCOVERY 7(5) 522-538 2017年5月

T cell function is dispensable for intracranial aneurysm formation and progression. Haruka Miyata, Hirokazu Koseki, Katsumi Takizawa, Hidetoshi Kasuya, Kazuhiko Nozaki, Shuh Narumiya, Tomohiro Aoki. PLOS ONE 12(4) e0175421-- 2017年4月

Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Aoki T, Fr?sen J, Fukuda M, Bando K, Shioi G, Tsuji K, Ollikainen E, Nozaki K, Laakkonen J, Narumiya S. Science signaling 10(465) --- 2017年2月

Prostaglandin E2-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment. Aoki T, Narumiya S. Inflammation and regeneration 37(-) 4-- 2017年

Targeting macrophages to treat intracranial aneurysm. Tomohiro Aoki, Rie Yamamoto, Shuh Narumiya. Oncotarget 8(62) 104704-104705 2017年

書籍

青木友浩
脳動脈瘤の発生と破裂の分子生物学的メカニズム. 野崎和彦, 青木友浩. プライム脳神経外科. 三輪書店 2017

川村将仁
Ketogenic diet in a hippocampal slice: models and mechanisms. Kawamura M, Jr.. Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease. Oxford University Press 2017

論文

青木友浩
Future prospects for the development of a novel medical therapy for intracranial aneurysm. Aoki T. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 148(2) 86-91 2016年8月

What senses shear stress? Aoki T. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 148(2) 123-123 2016年8月

Sustained expression of MCP-1 by low wall shear stress loading concomitant with turbulent flow on endothelial cells of intracranial aneurysm. Tomohiro Aoki, Kimiko Yamamoto, Miyuki Fukuda, Yuji Shimogonya, Shunichi Fukuda, Shuh Narumiya. ACTA NEUROPATHOLOGICA COMMUNICATIONS 4(1) 48-- 2016年5月

[Can an antagonist for prostaglandin receptor be an alternative of aspirin?]. Aoki T. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 147(4) 253-253 2016年4月

Prostaglandin E2-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways. Ma X, Aoki T, Narumiya S. Cellular & molecular immunology 13(2) 240-250 2016年3月

Preemptive Medicine for Cerebral Aneurysms. Tomohiro Aoki, Kazuhiko Nozaki. NEUROLOGIA MEDICO-CHIRURGICA 56(9) 552-568 2016年

Fundamentals of physiology and biology of vascular system. Tomohiro Aoki, Kimiko Yamamoto. Vascular Engineering: New Prospects of Vascular Medicine and Biology with a Multidiscipline Approach 47-68 2016年1月

Population of inflammatory cells in intracranial aneurysm with the special insight to the development of novel diagnostic and therapeutic approaches. Koseki H, Aoki T. Neuroimmunology and Neuroinflammation 3 173-179 2016年

石川太郎
Dendritic excitation-inhibition balance shapes cerebellar output during motor behaviour. Marta Jelitai, Paolo Puggioni, Taro Ishikawa, Arianna Rinaldi, Ian Duguid. Nature communications 7 13722-13722 2016年12月

川村将仁
Metabolic Therapy for Temporal Lobe Epilepsy in a Dish: Investigating Mechanisms of Ketogenic Diet using Electrophysiological Recordings in Hippocampal Slices. Masahito Kawamura, David N. Ruskin, Susan A. Masino. FRONTIERS IN MOLECULAR NEUROSCIENCE 9 112 2016年

西晴久
IgE Receptor-Mediated Histamine Release in Human Lung Mast Cells: Modulation by Purinergic Receptor Ligands. Haruhisa Nishi, Amir Pelleg, Edward S. Schulman. ANNALS OF CLINICAL AND LABORATORY SCIENCE 46(5) 463-469 2016年9月

鈴木江津子
PSD-95 regulates synaptic kainate receptors at mouse hippocampal mossy fiber-CA3 synapses. Etsuko Suzuki, Haruyuki Kamiya. NEUROSCIENCE RESEARCH 107 14-19 2016年6月

論文

青木友浩
Definition of Prostaglandin E-2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth. Xiaojun Ma, Tomohiro Aoki, Tatsuaki Tsuruyama, Shuh Narumiya. CANCER RESEARCH 75(14) 2822-2832 2015年7月

The CCAAT/enhancer-binding protein delta/miR135a/thrombospondin 1 axis mediates PGE2-induced angiogenesis in Alzheimer's disease. Chiung-Yuan Ko, Yu-Yi Chu, Shuh Narumiya, Jhih-Ying Chi, Tomoyuki Furuyashiki, Tomohiro Aoki, Shao-Ming Wang, Wen-Chang Chang, Ju-Ming Wang. NEUROBIOLOGY OF AGING 36(3) 1356-1368 2015年3月

Primate Model of Intracranial Aneurysm to Examine the Effect of Drugs on Aneurysm Growth. Keiichi Tsuji, Makoto Saito, Toshihiro Yokoi, Tomohiro Aoki, Kazuhiko Nozaki. STROKE 46 2015年2月

石川太郎、　志牟田美佐
Multimodal sensory integration in single cerebellar granule cells in vivo. Taro Ishikawa, Misa Shimuta, Michael Häusser. eLife 4 2015年12月

中村行宏
Ca2+ Channel to Synaptic Vesicle Distance Accounts for the Readily Releasable Pool Kinetics at a Functionally Mature Auditory Synapse. Zuxin Chen, Brati Das, Yukihiro Nakamura, David A. DiGregorio, Samuel M. Young. JOURNAL OF NEUROSCIENCE 35(5) 2083-2100 2015年2月

Nanoscale Distribution of Presynaptic Ca2+ Channels and Its Impact on Vesicular Release during Development. Yukihiro Nakamura, Harumi Harada, Naomi Kamasawa, Ko Matsui, Jason S. Rothman, Ryuichi Shigemoto, R. Angus Silver, David A. DiGregorio, Tomoyuki Takahashi. NEURON 85(1) 145-158 2015年1月

書籍

青木友浩
脳動脈瘤の基礎研究. 青木 友浩. 未破裂脳動脈瘤 Japan Standard. 中外医学社 2015

脳動脈瘤発生・増大・破裂のメカニズム. 青木 友浩. 脳神経外科診療プラクティス５「無症候性脳血管障害を解く」. 文光堂 2015

論文

青木友浩
Exacerbation of Intracranial Aneurysm and Aortic Dissection in Hypertensive Rat Treated With the Prostaglandin F-Receptor Antagonist AS604872. Miyuki Fukuda, Tomohiro Aoki, Toshiaki Manabe, Akiko Maekawa, Takayuki Shirakawa, Hiroharu Kataoka, Yasushi Takagi, Susumu Miyamoto, Shuh Narumiya. JOURNAL OF PHARMACOLOGICAL SCIENCES 126(3) 230-242 2014年11月

Differential Gene Expression in Relation to the Clinical Characteristics of Human Brain Arteriovenous Malformations. Yasushi Takagi, Tomohiro Aoki, Jun C. Takahashi, Kazumichi Yoshida, Akira Ishii, Yoshiki Arakawa, Takayuki Kikuchi, Takeshi Funaki, Susumu Miyamoto. NEUROLOGIA MEDICO-CHIRURGICA 54(3) 163-175 2014年3月

Statin Use and Risk of Cerebral Aneurysm Rupture: A Hospital-based Case-control Study in Japan. Yayoi Yoshimura, Yoshitaka Murakami, Makoto Saitoh, Toshihiro Yokoi, Tomohiro Aoki, Katsuyuki Miura, Hirotsugu Ueshima, Kazuhiko Nozaki. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 23(2) 343-348 2014年2月

Critical role of TNF-alpha-TNFR1 signaling in intracranial aneurysm formation. Tomohiro Aoki, Miyuki Fukuda, Masaki Nishimura, Kazuhiko Nozaki, Shuh Narumiya. ACTA NEUROPATHOLOGICA COMMUNICATIONS 2(-) 34-- 2014年

Molecular basis for intracranial aneurysm formation. Miyuki Fukuda, Tomohiro Aoki. Acta Neurochirurgica, Supplementum 120 13-15 2014年

川村将仁
Ketogenic diet sensitizes glucose control of hippocampal excitability. Masahito Kawamura, David N. Ruskin, Jonathan D. Geiger, Detlev Boison, Susan A. Masino. JOURNAL OF LIPID RESEARCH 55(11) 2254-2260 2014年11月

Adenosine Receptors and Epilepsy. Susan A. Masino, Masahito Kawamura, David N. Ruskin International Review of Neurobiology 233-255 2014年

書籍

青木友浩
脳血管疾患の遺伝子異常の検索の意義. 青木 友浩. 脳神経外科周術期管理のすべて（改訂第4版）. メジカルビュー社 2014

脳動脈瘤形成機序の最新の知見と脳動脈瘤治療法変革への展望. 青木 友浩. 先端医療シリーズ45「臨床医のための最新脳神経外科」. （株）寺田国際事務所／先端医療技術研究所 2014

論文

青木友浩
Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis. Sadanori Watanabe, Tihana De Zan, Toshimasa Ishizaki, Shingo Yasuda, Hiroshi Kamijo, Daisuke Yamada, Tomohiro Aoki, Hiroshi Kiyonari, Hiroshi Kaneko, Ritsuko Shimizu, Masayuki Yamamoto, Gohta Goshima, Shuh Narumiya. CELL REPORTS 5(4) 926-932 2013年11月

Erratum: Ets-1 promotes the progression of cerebral aneurysm by inducing the expression of MCP-1 in vascular smooth muscle cells. T. Aoki, H. Kataoka, M. Nishimura, R. Ishibashi, R. Morishita, S. Miyamoto. Gene Therapy 20(2) 235- 2013年

川村将仁
Homeostatic control of brain function - New approaches to understand epileptogenesis. Detlev Boison, Ursula S. Sandau, David N. Ruskin, Masahito Kawamura Jr., Susan A. Masino. Frontiers in Cellular Neuroscience 7(JUNE) 109 2013年6月

Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice. David N. Ruskin, Julia Svedova, Jessica L. Cote, Ursula Sandau, Jong M. Rho, Masahito Kawamura Jr., Detlev Boison, Susan A. Masino. PLoS ONE 8(6) e65021 2013年6月

Adenosine and autism: A spectrum of opportunities. Susan A. Masino, Masahito Kawamura, Jessica L. Cote, Rebecca B. Williams, David N. Ruskin. NEUROPHARMACOLOGY 68 116-121 2013年5月

西晴久
NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca²⁺-mobilization/influx and cortisol secretion. Nishi H, Arai H, Momiyama T. PloS one 8(8) e71022 2013年8月

書籍

川村将仁
adenosine and autocrine metabolic regulation of neuronal activity. Kawamura M, Jr, Ruskin DN. Adenosine: a Key Link between Metabolism and CNS Activity. Springer Nature 2013

中村行宏
脳・神経科学の研究ガイド（分担執筆）. Carter, Matt, Shieh, Jennifer C., 小島, 比呂志, 中村 行宏, 二見, 高弘. 朝倉書店 2013年

論文

青木友浩
Prostaglandins and chronic inflammation. Tomohiro Aoki, Shuh Narumiya. TRENDS IN PHARMACOLOGICAL SCIENCES 33(6) 304-311 2012年6月

Regression of intracranial aneurysms by simultaneous inhibition of nuclear factor-κB and Ets with chimeric decoy oligodeoxynucleotide treatment. T. Aoki, H. Kataoka, M. Nishimura, R. Ishibashi, R. Morishita, S. Miyamoto. Neurosurgery 70(6) 1534-1543 2012年6月

Imidapril Inhibits Cerebral Aneurysm Formation in an Angiotensin-Converting Enzyme-Independent and Matrix Metalloproteinase-9-Dependent Manner. Ryota Ishibashi, Tomohiro Aoki, Masaki Nishimura, Susumu Miyamoto. NEUROSURGERY 70(3) 722-730 2012年3月

Erratum: Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. T. Aoki, M. Nishimura, H. Kataoka, R. Ishibashi, K. Nozaki, S. Miyamoto. Laboratory Investigation 92(12) 1802- 2012年

Erratum: Regression of intracranial aneurysms by simultaneous inhibition of nuclear factor-kB and ets with chimeric decoy oligodeoxynucleotide treatment. T. Aoki, H. Kataoka, M. Nishimura, R. Ishibashi, R. Morishita, S. Miyamoto. Neurosurgery 71(2) 502- 2012年

川村将仁
Purines and neuronal excitability: Links to the ketogenic diet. S.A. Masino, M. Kawamura, D.N. Ruskin, J.D. Geiger, D. Boison. Epilepsy Research 100(3) 229-238 2012年7月

鈴木江津子
Stratum oriens stimulation-evoked modulation of hippocampal long-term potentiation involves the activation of muscarinic acetylcholine receptors and the inhibition of Kv7/M potassium ion channels. Etsuko Suzuki, Takashi Okada. EUROPEAN JOURNAL OF NEUROSCIENCE 36(1) 1984-1992 2012年7月

書籍

青木友浩
未破裂脳動脈瘤に対する薬物治療. 青木友浩, 野崎和彦. 神経疾患最新の治療 2012-2014.南江堂 2012

中村行宏
Patch-clamp recording method in slices for studying presynaptic mechanisms（分担執筆）. Tomoyuki Takahashi, Tetsuya Hori, Yukihiro Nakamura, Takayuki Yamashita. Springer Nature 2012年

論文

青木友浩
Single and Local Blockade of Interleukin-6 Signaling Promotes Neuronal Differentiation From Transplanted Embryonic Stem Cell-Derived Neural Precursor Cells. Masanori Gomi, Tomohiro Aoki, Yasushi Takagi, Masaki Nishimura, Yoshiyuki Ohsugi, Masahiko Mihara, Kazuhiko Nozaki, Nobuo Hashimoto, Susumu Miyamoto, Jun Takahashi. JOURNAL OF NEUROSCIENCE RESEARCH 89(9) 1388-1399 2011年9月

Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake. Tomoyuki Mitsumori, Tomoyuki Furuyashiki, Toshihiko Momiyama, Akinori Nishi, Takahide Shuto, Takashi Hayakawa, Fumitaka Ushikubi, Shiho Kitaoka, Tomohiro Aoki, Haruhisa Inoue, Toshiyuki Matsuoka, Shuh Narumiya. EUROPEAN JOURNAL OF NEUROSCIENCE 34(4) 594-604 2011年8月

PGE 2-EP 2 signalling in endothelium is activated by haemodynamic stress and induces cerebral aneurysm through an amplifying loop via NF-κB. T. Aoki, M. Nishimura, T. Matsuoka, K. Yamamoto, T. Furuyashiki, H. Kataoka, S. Kitaoka, R. Ishibashi, A. Ishibazawa, S. Miyamoto, R. Morishita, J. Ando, N. Hashimoto, K. Nozaki, S. Narumiya. British Journal of Pharmacology 163(6) 1237-1249 2011年7月

Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. Tomohiro Aoki, Masaki Nishimura, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Susumu Miyamoto. LABORATORY INVESTIGATION 91(4) 619-626 2011年4月

Expression of thioredoxin-1 and hypoxia inducible factor-1α in cerebral arteriovenous malformations: Possible role of redox regulatory factor in neoangiogenic property. Takagi Y, Kikuta K, Moriwaki T, Aoki T, Nozaki K, Hashimoto N, Miyamoto S. Surgical neurology international 2 61 2011年

The Development and the Use of Experimental Animal Models to Study the Underlying Mechanisms of CA Formation. Tomohiro Aoki, and Masaki Nishimura. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY 2011 535921 2011年

川村将仁
The relationship between the neuromodulator adenosine and behavioral symptoms of autism. Susan A. Masino, Masahito Kawamura, Louisa M. Plotkin, Julia Svedova, Francis J. DiMario, Inge-Marie Eigsti. NEUROSCIENCE LETTERS 500(1) 1-5 2011年8月

A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease. David N. Ruskin, Jessica L. Ross, Masahito Kawamura, Tiffany L. Ruiz, Jonathan D. Geiger, Susan A. Masino. PHYSIOLOGY & BEHAVIOR 103(5) 501-507 2011年7月

Long-term facilitation of spontaneous calcium oscillations in astrocytes with endogenous adenosine in hippocampal slice cultures. Masahito Kawamura, Masahiro Kawamura. CELL CALCIUM 49(4) 249-258 2011年4月

鈴木江津子
The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields. Etsuko Suzuki, Makiko Sato, Ryota Takezawa, Toyonobu Usuki, Takashi Okada. JOURNAL OF PHYSIOLOGICAL SCIENCES 61(5) 421-427 2011年9月

書籍

川村将仁
Adenosine and Autism - Recent Research and a New Perspective. Masino SA, Kawamura M, Jr, Svedova J, Dimario FJ, J, Eigsti IM. Autism - A Neurodevelopmental Journal from Genes to Behaviour. InTech 2011

中村行宏
最新パッチクランプ実験技術法（分担執筆）. 中村行宏. 吉岡書店 2011年

論文

青木友浩
Molecular mechanism of cerebral aneurysm formation focusing on NF-κB as a key mediator of inflammation. T. Aoki, M. Nishimura. Journal of Biorheology 24(1) 16-21 2010年12月

Toll-like receptor 4 expression during cerebral aneurysm formation. Tomohiro Aoki, Masaki Nishimura, Ryota Ishibashi, Hiroharu Kataoka, Yasushi Takagi, Nobuo Hashimoto. JOURNAL OF NEUROSURGERY 113(4) 851-858 2010年10月

Ets-1 promotes the progression of cerebral aneurysm by inducing the expression of MCP-1 in vascular smooth muscle cells. T. Aoki, H. Kataoka, M. Nishimura, R. Ishibashi, R. Morishita, S. Miyamoto. GENE THERAPY 17(9) 1117-1123 2010年9月

Contribution of Mast Cells to Cerebral Aneurysm Formation. Ryota Ishibashi, Tomohiro Aoki, Masaki Nishimura, Nobuo Hashimoto, Susumu Miyamoto. CURRENT NEUROVASCULAR RESEARCH 7(2) 113-124 2010年5月

Targeting chronic inflammation in cerebral aneurysms: Focusing on NF-κB as a putative target of medical therapy. T. Aoki, M. Nishimura. Expert Opinion on Therapeutic Targets 14(3) 265-273 2010年3月

Molecular basis for the development of intracranial aneurysm. Hiroharu Kataoka, Tomohiro Aoki. EXPERT REVIEW OF NEUROTHERAPEUTICS 10(2) 173-187 2010年2月

川村将仁
Metabolic Autocrine Regulation of Neurons Involves Cooperation among Pannexin Hemichannels, Adenosine Receptors, and K-ATP Channels. Masahito Kawamura, David N. Ruskin, Susan A. Masino. JOURNAL OF NEUROSCIENCE 30(11) 3886-3895 2010年3月

Purines and the Anti-Epileptic Actions of Ketogenic Diets. Masino SA, Kawamura M Jr, Ruskin DN, Gawryluk J, Chen X, Geiger JD. The open neuroscience journal 4(1) 58-63 2010年1月

Control of Cannabinoid CB1 Receptor Function on Glutamate Axon Terminals by Endogenous Adenosine Acting at A(1) Receptors. Alexander F. Hoffman, Nora Laaris, Masahito Kawamura, Susan A. Masino, Carl R. Lupica. JOURNAL OF NEUROSCIENCE 30(2) 545-555 2010年1月

鈴木江津子
Group I metabotropic glutamate receptors are involved in TEA-induced long-term potentiation at mossy fiber-CA3 synapses in the rat hippocampus. Etsuko Suzuki, Takashi Okada. BRAIN RESEARCH 1313 45-52 2010年2月

書籍

青木友浩
脳動脈瘤モデル. 横井俊浩, 青木友浩, 西村真樹, 野崎和彦. モデル動物利用マニュアル. エル・アイ・シー 2010

論文

青木友浩
The roles of tissue inhibitor of metalloproteinases 1 and 2 during cerebral ischemia-reperfusion injury. M. Gomi, M. Fujimoto, T. Aoki, M. Hayase, T. Marumo, M. Nishimura, Y. Takagi. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 29 S478-S479 2009年10月

Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats. Tomohiro Aoki, Masaki Nishimura, Hiroharu Kataoka, Ryota Ishibashi, Takashi Miyake, Yasushi Takagi, Ryuichi Morishita, Nobuo Hashimoto. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 24(3) 353-359 2009年9月

Reduced collagen biosynthesis is the hallmark of cerebral aneurysm: Contribution of interleukin-1β and nuclear factor-κB. T. Aoki, H. Kataoka, R. Ishibashi, K. Nozaki, R. Morishita, N. Hashimoto. Arteriosclerosis, Thrombosis, and Vascular Biology 29(7) 1080-1086 2009年7月

Reactive oxygen species modulate growth of cerebral aneurysms: a study using the free radical scavenger edaravone and p47phox(-/-) mice. Tomohiro Aoki, Masaki Nishimura, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Nobuo Hashimoto. LABORATORY INVESTIGATION 89(7) 730-741 2009年7月

Impact of Monocyte Chemoattractant Protein-1 Deficiency on Cerebral Aneurysm Formation Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Kensuke Egashira, Nobuo Hashimoto. STROKE 40(3) 942-951 2009年3月

PITAVASTATIN SUPPRESSES FORMATION AND PROGRESSION OF CEREBRAL ANEURYSMS THROUGH INHIBITION OF THE NUCLEAR FACTOR kappa B PATHWAY. Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Hironori Nakagami, Kazuhiko Nozaki, Ryuuichi Morishita, Nobuo Hashimoto. NEUROSURGERY 64(2) 357-365 2009年2月

川村将仁
Reduced Pain and Inflammation in Juvenile and Adult Rats Fed a Ketogenic Diet. David N. Ruskin, Masahito Kawamura, Susan A. Masino. PLOS ONE 4(12) e8349 2009年12月

Adenosine, Ketogenic Diet and Epilepsy: The Emerging Therapeutic Relationship Between Metabolism and Brain Activity. S. A. Masino, M. Kawamura, C. A. Wasser, L. T. Pomeroy, D. N. Ruskin. CURRENT NEUROPHARMACOLOGY 7(3) 257-268 2009年9月

中村行宏
Disruption of the Ether-a-go-go K+ Channel Gene BEC1/KCNH3 Enhances Cognitive Function. Akira Miyake, Shinji Takahashi, Yukihiro Nakamura, Kohei Inamura, Shun-ichiro Matsumoto, Shinobu Mochizuki, Masao Katou. JOURNAL OF NEUROSCIENCE 29(46) 14637-14645 2009年11月

鈴木江津子
TEA-induced long-term potentiation at hippocampal mossy fiber-CA3 synapses: Characteristics of its induction and expression. Etsuko Suzuki, Takashi Okada. BRAIN RESEARCH 1247 21-27 2009年1月

論文

青木友浩
Gene expression profile of the intima and media of experimentally induced cerebral aneurysms in rats by laser-microdissection and microarray techniques. Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Nobuo Hashimoto. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 22(5) 595-603 2008年11月

Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia. Motoaki Fujimoto, Yasushi Takagi, Tomohiro Aoki, Makoto Hayase, Takeshi Marumo, Masanori Gomi, Masaki Nishimura, Hiroharu Kataoka, Nobuo Hashimoto, Kazuhiko Nozaki. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 28(10) 1674-1685 2008年10月

Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Nobuo Hashimoto. STROKE 39(9) 2603-2610 2008年9月

The efficacy of apolipoprotein E deficiency in cerebral aneurysm formation. Tomohiro Aoki, Takuya Moriwaki, Yasushi Takagi, Hiroharu Kataoka, Jiho Yang, Kazuhiko Nozaki, Nobuo Hashimoto. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 21(4) 453-459 2008年4月

Simvastatin suppresses the progression of experimentally induced cerebral aneurysms in rats. Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Nobuo Hashimoto. STROKE 39(4) 1276-1285 2008年4月

Nifedipine inhibits the progression of an experimentally induced cerebral aneurysm in rats with associated down-regulation of NF-kappa B transcriptional activity. Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Nobuo Hashimoto. CURRENT NEUROVASCULAR RESEARCH 5(1) 37-45 2008年2月

脳動脈瘤の成因:実験的脳動脈瘤誘発動物モデルを用いたその発生機序の解明: NOを中心に. 福田 俊一, 橋本 信夫, 野崎 和彦, 青木 友浩, 西村 真樹. 日本バイオレオロジー学会誌 22(3) 1-8 2008年

Gene expression during the development of experimentally induced cerebral aneurysms. Nobutake Sadamasa, Kazuhiko Nozaki, Hiroko Kita-Matsuo, Sakae Saito, Takuya Moriwaki, Tomohiro Aoki, Satoshi Kawarazaki, Hiroharu Kataoka, Yasushi Takagi, Masatsune Ishikawa, Nobuo Hashimoto, Kikuya Kato. JOURNAL OF VASCULAR RESEARCH 45(4) 343-349 2008年

論文

青木友浩
NF-κB is a key mediator of cerebral aneurysm formation. T. Aoki, H. Kataoka, M. Shimamura, H. Nakagami, K. Wakayama, T. Moriwaki, R. Ishibashi, K. Nozaki, R. Morishita, N. Hashimoto. Circulation 116(24) 2830-2840 2007年12月

Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Tomohiro Aoki, Hiroharu Kataoka, Takuya Moriwaki, Kazuhiko Nozaki, Nobuo Hashimoto. STROKE 38(8) 2337-2345 2007年8月

Macrophage-derived matrix metalloproteinase-2 and-9 promote the progression of cerebral aneurysms in rats. Tomohiro Aoki, Hiroharu Kataoka, Masafumi Morimoto, Kazuhiko Nozaki, Nobuo Hashimoto. STROKE 38(1) 162-169 2007年1月

石川太郎
High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Ede A Rancz, Taro Ishikawa, Ian Duguid, Paul Chadderton, Séverine Mahon, Michael Häusser. Nature 450(7173) 1245-8 2007年12月

中村行宏
Developmental changes in potassium currents at the rat calyx of Held presynaptic terminal. Yukihiro Nakamura, Tomoyuki Takahashi. JOURNAL OF PHYSIOLOGY-LONDON 581(3) 1101-1112 2007年6月

鈴木江津子
Regional differences in GABAergic modulation for TEA-induced synaptic plasticity in rat hippocampal CA1, CA3 and dentate gyrus. Etsuko Suzuki, Takashi Okada. NEUROSCIENCE RESEARCH 59(2) 183-190 2007年10月

論文

青木友浩
Impaired progression of cerebral aneurysms in interleukin-1β-deficient mice. T. Moriwaki, Y. Takagi, N. Sadamasa, T. Aoki, K. Nozaki, N. Hashimoto. Stroke 37(3) 900-905 2006年3月

The evaluation of preoperative and postoperative frontal lobe functions in three operative cases of meningioma. Tomohiro Aoki, Yuzuru Tashiro, Kouji Fujita, Motohiro Kajiwara, Yoshie Matsuda. Neurological Surgery 34(2) 161-167 2006年2月

Parry-Romberg syndrome with a giant internal carotid artery aneurysm. Tomohiro Aoki, Yuzuru Tashiro, Kouji Fujita, Motohiro Kajiwara. Surgical Neurology 65(2) 170-173 2006年2月

論文

青木友浩
A case report of the chondroma arising from the falx cerebri. Tomohiro Aoki, Yuzuru Tashiro, Kouji Fujita, Motohiro Kajiwara. Neurological Surgery 33(10) 979-984 2005年10月

A case report of the diffuse axonal injury with special regards to the acute phase MRI findings. T. Aoki. No to shinkei. Brain and nerve 57(9) 806-807 2005年9月

石川太郎
Presynaptic N-type and P/Q-type Ca2+ channels mediating synaptic transmission at the calyx of Held of mice. Taro Ishikawa, Masahiro Kaneko, Hee-Sup Shin, Tomoyuki Takahashi. The Journal of physiology 568(Pt 1) 199-209 2005年10月

中村行宏
G protein-dependent presynaptic inhibition mediated by AMPA receptors at the calyx of Held. H Takago, Y Nakamura, T Takahashi. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 102(20) 7368-7373 2005年5月

論文

青木友浩
[The cerebellopontine angle lipoma with unusual findings on T2-weighted image]. Aoki T, Ishizaki R, Saiki M, Sato T. No to shinkei = Brain and nerve 56(8) 718-719 2004年8月

Reversible hyperintensity lesion on diffusion-weighted MRI in hypoglycemic coma. Tomohiro Aoki, T. Sato, K. Hasegawa, R. Ishizaki, M. Saiki. Neurology 63(2) 392-393 2004年7月

A case report of bilateral cerebral peduncular infarction manifesting tetraparesis and pseudobalbur palsy. Tomohiro Aoki, Masaaki Saiki, Ryuji Ishizaki, Takeshi Sato. Brain and Nerve 56(7) 575-578 2004年7月

[Cystic metastatic skull tumor]. Aoki T, Saiki M, Ishizaki R, Sato T. No to shinkei = Brain and nerve 56(3) 260-261 2004年3月

川村将仁
Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y(1) receptors in the hippocampal slice. M Kawamura, C Gachet, K Inoue, F Kato. JOURNAL OF NEUROSCIENCE 24(48) 10835-10845 2004年12月

Attenuation of gap-junction-mediated signaling facilitated anesthetic effect of sevoflurane in the central nervous system of rats. E Masaki, M Kawamura, F Kato. ANESTHESIA AND ANALGESIA 98(3) 647-652 2004年3月

ATP- and adenosine-mediated signaling in the central nervous system: Synaptic purinoceptors: the stage for ATP to play its "dual-role". F Kato, M Kawamura, E Shigetomi, J Tanaka, K Inoue. JOURNAL OF PHARMACOLOGICAL SCIENCES 94(2) 107-111 2004年2月

西晴久
Adenosine 5 '-(gamma-thio) triphosphate (ATP gamma S) stimulates both P2Y receptors linked to inositol phosphates production and cAMP accumulation in bovine adrenocortical fasciculata cells. H Nishi, S Hori, A Niitsu, M Kawamura. LIFE SCIENCES 74(9) 1181-1190 2004年1月

論文

石川太郎、　中村行宏
Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Taro Ishikawa, Yukihiro Nakamura, Naoto Saitoh, Wen-Bin Li, Shinichi Iwasaki, Tomoyuki Takahashi. The Journal of neuroscience : the official journal of the Society for Neuroscience 23(32) 10445-53 2003年11月

石川太郎
Developmental increase in vesicular glutamate content does not cause saturation of AMPA receptors at the calyx of Held synapse. Takayuki Yamashita, Taro Ishikawa, Tomoyuki Takahashi. The Journal of neuroscience : the official journal of the Society for Neuroscience 23(9) 3633-8 2003年5月

川村将仁
Analysis of the molecular mechanisms controlling synaptic transmission by patch-clamp recording in brainstem slices. Fusao Kato, Eiji Shigetomi, Masahito Kawamura, Ryo Ikeda. Folia Pharmacologica Japonica 121(4) 255-263 2003年

論文

石川太郎
A single packet of transmitter does not saturate postsynaptic glutamate receptors. Taro Ishikawa, Yoshinori Sahara, Tomoyuki Takahashi. Neuron 34(4) 613-21 2002年5月

西晴久
ADP-sensitive purinoceptors induce steroidogenesis via adenylyl cyclase activation in bovine adrenocortical fasciculata cells. H Nishi, T Kato, E Masaki, M Kawamura. BRITISH JOURNAL OF PHARMACOLOGY 137(2) 177-184 2002年9月

Phyllodulcin,a Constituent of “Amacha”,Inhibits Phosphodiestenase in Bovine Adrenocortical Cells. Kawamura M, Kagata M, Masaki E, Nishi H. Pharmacology & Toxicology 90(2) 106-108 2002年2月

志牟田美佐
神経可塑性及び空間認知におけるHNK-1糖鎖の役割. 岡 昌吾, 山本 昌司, 井上 満博, 志牟田 美佐, 真鍋 俊也, 高橋 秀樹, 宮本 政臣, 川嵜 敏祐. 生化学 74(8) 854-854 2002年8月

Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning. S Yamamoto, S Oka, M Inoue, M Shimuta, T Manabe, M Takahashi, M Miyamoto, M Asano, J Sakagami, K Sudo, Y Iwakura, K Ono, T Kawasaki. JOURNAL OF BIOLOGICAL CHEMISTRY 277(30) 27227-27231 2002年7月

論文

石川太郎
Mechanisms underlying presynaptic facilitatory effect of cyclothiazide at the calyx of Held of juvenile rats. T Ishikawa, T Takahashi. The Journal of physiology 533(Pt 2) 423-31 2001年6月

川村将仁
Reduction by sevoflurane of adenosine 5′-triphosphate-activated inward current of locus coeruleus neurons in pontine slices of rats. Eiji Masaki, Masahito Kawamura, Fusao Kato. Brain Research 921(1-2) 226-232 2001年12月

西晴久
Extracellular ATP potentiates steroidogenic effect of adrenocorticotropic hormone in bovine adrenocortical fasciculata cells. M Kawamura, A Niitsu, H Nishi, E Masaki. JAPANESE JOURNAL OF PHARMACOLOGY 85(4) 376-381 2001年4月

甘茶主成分であるフィロズルシンのウシ副腎皮質細胞におけるステロイドホルモン産生に対する影響. 林田 恵子, 村上 稔, 西 晴久. 東京慈恵会医科大学雑誌 116(1) 1-6 2001年1月

The anesthetic interaction between adenosine triphosphate and N-methyl-D-aspartate receptor antagonists in the rat. Masaki E, Yamazaki K, Ohno Y, Nishi H, Matsumoto Y, Kawamura M. Anesthesiology Analgesia 92(1) 134-139 2001年1月

志牟田美佐
Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor. M Shimuta, M Yoshikawa, M Fukaya, M Watanabe, H Takeshima, T Manabe. MOLECULAR AND CELLULAR NEUROSCIENCE 17(5) 921-930 2001年5月

論文

川村将仁
Distinct responses to ATP of identified neurons in mesencephalic trigeminal nucleus and locus coeruleus in the rat pontine slice. F Kato, M Kawamura, E Masaki. CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS 1208 411-412 2000年

西晴久
細胞外adenosine 5’-triphosphateのウシ副腎皮質ホルモン産生促進作用に対するprotein kinase C の関与. 小沼 康男, 林田 恵子, 西 晴久. 慈恵医大誌 Vol.115, pp.527-533. 2000年